Trivalent Gadolinium Ions Forming Injectable Hydrogels for Simultaneous In Situ Vaccination Therapy and Imaging of Soft Tissue Sarcoma
provides the ability of magnetic resonance imaging (MRI), meanwhile, further cross-linking the hydrogel network. Experiments show excellent ability of sustained release and imaging tracking for the hydrogel platform. In mouse STS models, the "in situ vaccination" hydrogels show the best effect of inhibiting tumor growth. Further analysis of tumor tissues shows that the "in situ vaccination" group can increase T cell infiltration, promote M1-type macrophage polarization and block elevated PD-1/PD-L1 pathway caused by DOX. These results are expected to prove the potential for synthesized hydrogels to achieve a universal platform for "in situ vaccination" strategies on STS treatments.
Authors
- Yirong Wu (ORCID: https://orcid.org/0000-0002-4364-8654)
- Anni Chen (ORCID: https://orcid.org/0009-0003-1131-6115)
- Ju Gu (ORCID: https://orcid.org/0000-0003-0626-2688)
- Aoxing Chen
- Zijian Wei
- Lanqi Cen
- B Liu
- Shoufeng Wang (ORCID: https://orcid.org/0000-0002-5575-5772)
- Xiaowen He (ORCID: https://orcid.org/0009-0008-5205-9676)
- Yuanhao Jing
- R J Li
- C S Wang
- Ying‐Tzu Yen
- Xueru Song
- Gaojian Tao
- Lixia Yu
- Bin Xue (ORCID: https://orcid.org/0000-0002-0822-6501)
- Wenting Yu
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Traditional Chinese Medicine Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Jiangsu Cancer Hospital (CN)
- Collaborative Innovation Center of Advanced Microstructures (CN)
- The Synergetic Innovation Center for Advanced Materials (CN)
Publication Details
- Journal
- Advanced Healthcare Materials
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1002/adhm.71182
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00