Supramolecular Visualized Chemotherapy Based on OxPt-TTVP@CB[8]: Activating Oxidative Damage to Induce ICD for Enhancing the Killing of Tumor Cells
, respectively, compared with the control group. Transcriptomic analysis revealed upregulation of pathways related to immune activation, suggesting that OTC treatment primed the tumor for immunotherapy. The possible biological mechanism behind this was that OTC activated oxidative damage to induce immunogenic cell death (ICD). Overall, OTC offers a simple, visual, and highly efficient method for transporting platinum to improve chemotherapy. It also provides a novel strategy for combining chemotherapy and immunotherapy in solid tumors.
Authors
- Qinye Liu
- Tong Ye (ORCID: https://orcid.org/0009-0001-0620-2477)
- Zhaoxiang Li (ORCID: https://orcid.org/0009-0003-8255-433X)
- Guifeng Kang (ORCID: https://orcid.org/0000-0002-2196-4621)
- Yueyue Chen
- Hui Gan (ORCID: https://orcid.org/0009-0009-8544-0913)
Institutions
- Capital University (US)
- Capital Medical University (CN)
- Academy of Military Medical Sciences (CN)
- United States Air Force (US)
- Air Force Medical University (CN)
Publication Details
- Journal
- Langmuir
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1021/acs.langmuir.6c01088
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00