Ca <sup>2+</sup> ‐Activated Cl <sup>−</sup> Channels: Do Bestrophins and <scp>TMEM16A</scp> Interact?
AIM: -activated Cl- conductances. METHODS: In this review, we discuss the possibility that members of the two families, bestrophins and TMEM16A, may interact. RESULTS: independently of membrane potential, and both proteins are importantly associated with inflammation and pain transmission. However, it seems that little testing of a direct interaction of TMEM16A and bestrophins has been published. CONCLUSION: We conclude that there is evidence for direct interaction between TMEM16A and bestrophins in the cardiovascular system, and it will be important to determine whether similar interactions extend to other tissues.
Authors
- Holger Nilsson (ORCID: https://orcid.org/0000-0003-2350-7157)
- Vibeke Secher Dam (ORCID: https://orcid.org/0000-0003-2925-6416)
- Donna B. Boedtkjer
- Vladimir Matchkov (ORCID: https://orcid.org/0000-0002-3303-1095)
- Christian Aalkjær (ORCID: https://orcid.org/0000-0003-2618-4015)
Institutions
- Aarhus University (DK)
- University of Gothenburg (SE)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1111/apha.70232
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00