Integrin‐Targeted Delivery of Redox Homeostasis Regulating Lanthanide‐Based Composite Nanoplatform for Deep Self‐Enhanced Photodynamic/H <sub>2</sub> S Gas Synergistic Therapy via 1530 nm Activation
S generated by the reaction of DATS with GSH can produce a gas therapy (GT) effect. The active targeting effect of cRGD-PEG increases UMDP accumulation at the tumor site. The key advantage of UMDP lies in breakthrough tissue penetration depth and the mutually reinforcing therapy mechanisms, which overcome the bottleneck of traditional PDT and provide a novel strategy for enhancing the PDT/GT synergistic effect of deep-seated tumors.
Authors
- Yi Zhou (ORCID: https://orcid.org/0000-0002-0273-007X)
- Jitong Gong (ORCID: https://orcid.org/0000-0002-7856-7352)
- Ye Lu (ORCID: https://orcid.org/0000-0002-2376-4519)
- Yukai Cheng
- Jing Feng (ORCID: https://orcid.org/0000-0003-2850-0990)
- Xinyu Fu
- Hongjie Zhang (ORCID: https://orcid.org/0000-0001-5433-8611)
- Ruohao Zhang (ORCID: https://orcid.org/0000-0002-8164-0098)
Institutions
- University of Science and Technology of China (CN)
- Changchun Institute of Applied Chemistry (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Advanced Healthcare Materials
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1002/adhm.71253
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00