Mouse precision-cut liver and kidney slices: an optimized <i>ex vivo</i> model for organotoxicity testing
system makes this valuable, reproducible, and ethically approved platform for testing nephrotoxicity and hepatotoxicity accessible to more laboratories, for example for dose finding or compound prioritisation, thereby supporting 3R-conform preclinical drug screening as well as hazard identification and potentially reducing reliance on animal experiments.
Authors
- Gerhard Fritz (ORCID: https://orcid.org/0000-0002-9942-2726)
- Andreas Dimitriadis
- Christiane Spruck
- Nicole Schupp (ORCID: https://orcid.org/0000-0002-1836-6348)
- Isaac Musong Mboni-Johnston
- Ghizlan Bousejra
- Ahmed Erbay
- Zoe Röntgen
- Frauke Roolfs
- S Hammad
- Sonja Herbrich
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Düsseldorf University Hospital (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Toxicology Mechanisms and Methods
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1080/15376516.2026.2670503
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00