Unified TCM Formula + Western Drug Nature Score Atlas: Paper 8 of the Genesis Geometric Medicine Series -- Three-Layer Thermal Architecture and Integrative Prescribing Matrix

Paper 8 of the Genesis Geometric Medicine Series synthesizes three prior papers into a unified Nature Score (NS) axis spanning 79 compounds (50 TCM formulas + 29 Western drugs). Six validated equivalence pairs include Metoprolol vs Zhi Bai Rehmannia (delta NS=0.02) and Enalapril vs Polyporus Decoction (exact NS=-0.80 match). The three-layer architecture (TPSA / formula NS / lambda2) resolves the TPSA-formula paradox. Key finding: no Western drug reaches NS > +1.2 or NS < -1.5, defining the irreplaceable thermal space of TCM formulas. Integrative prescribing matrix for 7 clinical scenarios. Genesis Framework v4, n=79 compounds.