Prenatal Counseling Conundrum: Unexpectedly Mild Phenotype in a Pregnant Woman with Homozygous CD41/42(-TTCT) β-Thalassemia

γ + 25 G > A). Because her husband was also a heterozygous carrier of the same mutation, prenatal diagnosis was performed and indicated a homozygous CD41/42(-TTCT) genotype in the fetus. This marked genotype-phenotype discordance in the pregnant woman posed a significant challenge for prenatal genetic counseling. Ultimately, given the current limitations in understanding such phenotypic variations, the couple decided to terminate the pregnancy.