Design of pyrrolidine-2, 5-dione Schiff's base derivatives as GABAA inhibitors for antiepileptic activity

Succinimide derivatives are an essential class of compounds with diverse pharmacological applications. Different derivatives of succinimide as Schiff’s base were designed for good inhibitory activity against the human GABAA receptor. Compounds that inhibit GABAA are effective as anti-epileptic agents. Virtual screening methods, such as chemical absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties, play key roles in drug discovery and development, and molecular docking was used. ADMET properties and drug likeliness of all investigated compounds were predicted by Swiss ADMET software. A higher binding affinity and interactions have been observed with the designed compounds compared to the standard compounds (phenobarbital and flumazenil).