Classical TCM Formula Four-Qi Geometric Atlas: 50-Formula Validation with NRICM101 Analysis — Therapeutic Category as Perfect Predictor of Nature Score (Spearman rho=1.000)

Paper 7 of Genesis Geometric Medicine Series. 50 classical TCM formulas (12 therapeutic categories) analyzed with Nature Score (NS), TPSA, Q_LTE, GII. KEY RESULT: Therapeutic category predicts NS with Spearman rho=1.000 (p<0.001) vs TCM tradition rank. Kruskal-Wallis H=30.6, p=0.0013**. Warm-Interior NS=+0.82 vs Heat-Clearing NS=-1.41, Cohen d=1.95. HONEST NEGATIVE: TPSA does NOT predict NS at formula level (rho=-0.09) due to macro-molecule saponin dilution — explained by three-layer architecture. NRICM101 (Qing Guan Yi Hao, COVID-19): NS=-0.44 [Yin-Cool], deliberate warm-herb modulation prevents Yang suppression while clearing heat. Computational prescribing algorithm updated for 50-formula atlas.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-05-13
DOI
https://doi.org/10.5281/zenodo.20161745
Primary Topic
Traditional Chinese Medicine Studies
Type
preprint
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preprint

Classical TCM Formula Four-Qi Geometric Atlas: 50-Formula Validation with NRICM101 Analysis — Therapeutic Category as Perfect Predictor of Nature Score (Spearman rho=1.000)

Yao-Kai Kao
Zenodo (CERN European Organization for Nuclear Research)
Traditional Chinese Medicine Studies
preprint

Classical TCM Formula Four-Qi Geometric Atlas: 50-Formula Validation with NRICM101 Analysis — Therapeutic Category as Perfect Predictor of Nature Score (Spearman rho=1.000)

Yao-Kai Kao
preprint en

Abstract

Paper 7 of Genesis Geometric Medicine Series. 50 classical TCM formulas (12 therapeutic categories) analyzed with Nature Score (NS), TPSA, Q_LTE, GII. KEY RESULT: Therapeutic category predicts NS with Spearman rho=1.000 (p<0.001) vs TCM tradition rank. Kruskal-Wallis H=30.6, p=0.0013**. Warm-Interior NS=+0.82 vs Heat-Clearing NS=-1.41, Cohen d=1.95. HONEST NEGATIVE: TPSA does NOT predict NS at formula level (rho=-0.09) due to macro-molecule saponin dilution — explained by three-layer architecture. NRICM101 (Qing Guan Yi Hao, COVID-19): NS=-0.44 [Yin-Cool], deliberate warm-herb modulation prevents Yang suppression while clearing heat. Computational prescribing algorithm updated for 50-formula atlas.

Zenodo (CERN European Organization for Nuclear Research)
Allen Institute for Brain Science (US)
Traditional Chinese Medicine Studies
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