Cross-species transcriptomic integration reveals a MIRO1-mediated macrophage–T cell axis in glioma
signals from another cluster of macrophages (MAC4). Targeting MIRO1 eliminates this cell circuitry and reduces the tumor cell population. Our study provides a transcriptomic framework for understanding mitochondria-immune crosstalk and nominates MIRO1-PARP11 as a potential effector axis of brain immune dysfunction.
Authors
- Andy P. Tsai (ORCID: https://orcid.org/0000-0001-6400-544X)
- Kwang Bog Cho (ORCID: https://orcid.org/0000-0003-1776-734X)
- Menghan Li (ORCID: https://orcid.org/0009-0007-7030-4818)
- Brandon Hwa-Lin Bergsneider (ORCID: https://orcid.org/0000-0001-7013-8150)
- Lily H. Kim (ORCID: https://orcid.org/0000-0002-9272-019X)
- Zehui Du
- Gordon Li
- Tony Wyss-Coray (ORCID: https://orcid.org/0000-0001-5893-0831)
- John Choi
- Michael Lim
- Xinnan Wang (ORCID: https://orcid.org/0000-0002-2640-7082)
Institutions
- Neurosciences Institute (US)
- Stanford University (US)
Publication Details
- Journal
- Life Science Alliance
- Published
- 2026-05-13
- DOI
- https://doi.org/10.26508/lsa.202603749
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Wu Tsai Neurosciences Institute, Stanford University
- National Institute of General Medical Sciences
- National Institute of Neurological Disorders and Stroke