Antibiotics for Uncomplicated Acute Appendicitis

To the Editor The 10-year follow-up of the APPAC trial provides valuable long-term data supporting antibiotics as a feasible treatment option for uncomplicated acute appendicitis.1 However, several aspects of the analysis and its interpretation warrant clarification.

Authors

Theodore N. Pappas (ORCID: https://orcid.org/0000-0001-9110-4849)
Dimitrios Moris

Institutions

Georgetown University (US)
MedStar Georgetown University Hospital (US)
Duke Medical Center (US)

Publication Details

Journal: JAMA
Published: 2026-05-13
DOI: https://doi.org/10.1001/jama.2026.3808
Primary Topic: Appendicitis Diagnosis and Management
Type: article
Field-Weighted Citation Impact: 0.00

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article

Antibiotics for Uncomplicated Acute Appendicitis

Theodore N. Pappas, Dimitrios Moris

May 13, 2026

JAMA

Appendicitis Diagnosis and Management

article

Antibiotics for Uncomplicated Acute Appendicitis

Theodore N. Pappas, Dimitrios Moris

May 13, 2026article en

Abstract

JAMA

Georgetown University (US), MedStar Georgetown University Hospital (US), Duke Medical Center (US)

Good health and well-being

Openalex Percentile: Top 5%

Appendicitis Diagnosis and Management

DOI Source OpenAlex

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Antibiotics for Uncomplicated Acute Appendicitis — Theodore N. Pappas, Dimitrios Moris · JAMA (2026) | TGRS Research Map | TGRS