Single-nucleus sequencing dissects the malignant change of early lung adenocarcinoma: SMAD3 suppresses antitumor T cell immunity via ICAM1

T cells was found to dampen T cell-mediated antitumor response. In conclusion, these results reveal that the SMAD3-ICAM1 axis drives the malignant change from pulmonary nodules to early-stage LUAD, underscoring the potential of these molecules as biomarkers to inform diagnosis and surgical decision-making.

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Publication Details

Journal
npj Precision Oncology
Published
2026-05-12
DOI
https://doi.org/10.1038/s41698-026-01460-8
Primary Topic
Single-cell and spatial transcriptomics
Type
article
Field-Weighted Citation Impact
0.00

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article

Single-nucleus sequencing dissects the malignant change of early lung adenocarcinoma: SMAD3 suppresses antitumor T cell immunity via ICAM1

K Wang, Jigang Dai, Chengfei Yang, Peng Dai et al.
npj Precision Oncology
Single-cell and spatial transcriptomics
article

Single-nucleus sequencing dissects the malignant change of early lung adenocarcinoma: SMAD3 suppresses antitumor T cell immunity via ICAM1

K Wang, Jigang Dai, Chengfei Yang, Peng Dai, X M Deng, Zhuoxin Dai, Shuangqing Liao, Yanqi Li, Zhi Zheng, Xiaobing Liu, Quanxing Liu, Sijin Liu, Ziqi Huang
article en

Abstract

T cells was found to dampen T cell-mediated antitumor response. In conclusion, these results reveal that the SMAD3-ICAM1 axis drives the malignant change from pulmonary nodules to early-stage LUAD, underscoring the potential of these molecules as biomarkers to inform diagnosis and surgical decision-making.

npj Precision Oncology
Army Medical University (CN), Xinqiao Hospital (CN)
National Natural Science Foundation of China, Ministry of Education of the People's Republic of China, National Science and Technology Major Project
Peace, Justice and strong institutions
Openalex Percentile: Top 7%
Single-cell and spatial transcriptomics
DOIOpen Access PDFOpenAlex
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Single-nucleus sequencing dissects the malignant change of early lung adenocarcinoma: SMAD3 suppresses antitumor T cell immunity via ICAM1 — K Wang, Jigang Dai, et al. · npj Precision Oncology (2026) | TGRS Research Map | TGRS