Calofrasolide A, a new pyranocoumarin from the stem bark of <i>Calophyllum fraseri</i> M.R.Hend. & Wyatt-Sm. and their antimicrobial and antibiofilm activities
biofilms by 78.37 ± 0.22 %. Molecular docking studies supported the experimental findings, revealing favourable binding (LBE = -8.5 kcal/mol) within the active sites of ERG11 (5TZ1) and GtfB (8FK4). These findings highlight Calofrasolide A as a promising pyranocoumarin scaffold with potential antimicrobial and antibiofilm relevance, particularly against oral pathogenic infections.
Authors
- Nur Nabilah Mohd Zaini (ORCID: https://orcid.org/0009-0004-0847-489X)
- Mohd Hafiz Arzmi (ORCID: https://orcid.org/0000-0002-9470-6412)
- Abubakar Siddiq Salihu (ORCID: https://orcid.org/0000-0002-4425-7524)
- Nurulfazlina Edayah Rasol (ORCID: https://orcid.org/0000-0003-4696-5839)
- Wan Mohd Nuzul Hakimi Wan Salleh (ORCID: https://orcid.org/0000-0003-1408-229X)
- Nurunajah Ab Ghani
- Feruzbek A. Khasanov (ORCID: https://orcid.org/0000-0001-8534-6235)
- Sherali Kuziev
Institutions
- Sultan Idris Education University (MY)
- The University of Melbourne (AU)
- Umaru Musa Yar'adua University (NG)
- International Islamic University Malaysia (MY)
- Tashkent Islamic University (UZ)
- Oxford BioMedica (United Kingdom) (GB)
- Science Oxford (GB)
- National University of Uzbekistan (UZ)
- Universiti Teknologi MARA (MY)
- National University of Malaysia (MY)
Publication Details
- Journal
- Zeitschrift für Naturforschung C
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1515/znc-2025-0314
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00