Formulation and Evaluation of a Polyherbal Anti-Acne Face Wash Containing Matricaria chamomilla and Rubia cordifolia

Acne vulgaris is among the most prevalent dermatological conditions worldwide, affecting approximately 85% of adolescents and a significant proportion of adults. The increasing resistance to conventional antibiotics and adverse effects associated with synthetic formulations have driven renewed interest in herbal alternatives. The present investigation aimed to formulate and evaluate a polyherbal anti-acne face wash incorporating extracts of Matricaria chamomilla (German chamomile) and Rubia cordifolia (Indian madder/Manjistha) for their synergistic antimicrobial, anti-inflammatory, and sebum-regulating properties. Four formulations (F1–F4) were prepared with varying concentrations of herbal extracts and assessed for physicochemical parameters including pH (5.8–6.5), viscosity (2,200–3,100 cP), foam stability (82–96%), and skin irritation. Antimicrobial efficacy against Staphylococcus epidermidis and Propionibacterium acnes was evaluated using the agar diffusion method. Formulation F3 demonstrated superior performance with a zone of inhibition of 18.4 mm against P. acnes and 16.2 mm against S. epidermidis, comparable to the positive control (ciprofloxacin, 21.0 mm). All formulations passed stability studies at 40°C/75% RH for 90 days. The optimized formulation showed no skin sensitization in patch test studies. These findings support the therapeutic potential of the polyherbal face wash as a safe, effective, and sustainable approach to managing acne vulgaris.