Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study
ratios (T2-T3/PP) of biomarkers were 1.3-1.6, except for GCDCA-S and kynurenine where the ratios were ~5. The net renal secretory clearance and net unbound secretory clearance ratios of pyridoxic acid, p-cresol sulfate, p-cresol glucuronide, 3-indoxyl sulfate, and GCDCA-S were similar to the values listed above. Overall, OAT1/3 activity (as measured by endogenous biomarkers) is increased in T2-T3, consistent with available in vivo OAT1/3 substrate drug data. The studied biomarkers can be utilized in the future to quantify pregnancy-related changes in OAT1/3 transport activities across all trimesters.
Authors
- Jashvant D. Unadkat (ORCID: https://orcid.org/0000-0002-4820-8455)
- Aarzoo Thakur (ORCID: https://orcid.org/0000-0003-3906-5250)
- Nina Isoherranen (ORCID: https://orcid.org/0000-0002-9548-3126)
- Mary F. Hebert (ORCID: https://orcid.org/0000-0002-2530-8189)
- Emily E. Fay (ORCID: https://orcid.org/0000-0001-5582-2835)
Institutions
- University of Washington (US)
Publication Details
- Journal
- Clinical Pharmacology & Therapeutics
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1002/cpt.70321
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation
- National Institute of General Medical Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development