High‐Dimensional Immune Profiling Identifies Circulating <scp>NKT</scp> ‐Like Cells Associated With Severity Outcome in Acute Pancreatitis at Disease Onset
NKT-Like cells were found to be specifically reduced in ms-sAP patients. Moreover, NKT-Like cell subsets from these patients displayed an IL-15 induced expansion of NKG2a and NKp30 referred to mAP. Patients with AP at hospitalization with subsequent ms-sAP display a specific reduction of NKT-Like cells coupled with an expanded function. Hence, quantifying the phenotype and/or function of circulating NKT-Like cells during hospital admission could serve as a predictive biomarker for AP severity, aiding in early stratification and personalized treatment strategies.
Authors
- Hugo Gonzalo‐Benito (ORCID: https://orcid.org/0000-0001-8340-9909)
- Sara Cuesta‐Sancho (ORCID: https://orcid.org/0000-0002-9890-1063)
- Elisa Arribas‐Rodríguez (ORCID: https://orcid.org/0000-0002-4470-075X)
- Paloma Cal‐Sabater (ORCID: https://orcid.org/0000-0003-0267-794X)
- David Bernardo (ORCID: https://orcid.org/0000-0002-2843-6696)
- Álvaro Martín‐Muñoz (ORCID: https://orcid.org/0000-0002-6329-2827)
- Jessica Matesanz-Isabel
- Marina Perez-Mazzali
- Mª. Lourdes Ruiz Rebollo (ORCID: https://orcid.org/0000-0003-4600-9257)
- Carolina González de Castro (ORCID: https://orcid.org/0000-0001-9429-8386)
- Alejandro Gonzalez del Hierro (ORCID: https://orcid.org/0009-0002-1297-9474)
Institutions
- Universidad de Valladolid (ES)
- Centro de Investigación Biomédica en Red (ES)
- Instituto de Biomedicina y Genética Molecular de Valladolid (ES)
- Hospital Clínico Universitario de Valladolid (ES)
Publication Details
- Journal
- Immunology
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1111/imm.70143
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Junta de Castilla y León