Mild and Selective Oxidation of 4-Alkylpyridines to 4-Acylpyridines under an Oxygen Atmosphere
We report the exclusive conversion of 4-alkylpyridines to 4-acylpyridines. The reaction relies on the selective dearomatization of 4-alkylpyridines to the corresponding alkylidene dihydropyridines, which are oxidized under an oxygen atmosphere. This reaction avoids the use of metal catalysts and elevated temperatures and does not form ketones from 2- or 3-alkylpyridines or diactivated methylene.
Authors
- Ekadashi Pradhan (ORCID: https://orcid.org/0000-0002-5087-3761)
- Matthew Puzhitsky
- Faizan Rasheed
- Tao Zeng
- Andrei Nikolaev
- Brian Doan
- Arturo Orellana (ORCID: https://orcid.org/0000-0002-8372-2222)
Institutions
- York University (CA)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1021/acs.joc.6c00173
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00