Vital Roles of A-Type Linkage and Polymerization Degree in Governing Proanthocyanidin Interaction and Anti-inflammatory Action on Litchi Thaumatin-Like Protein
a = 283.7 L/mol) with LcTLP. Thermodynamic parameters indicated hydrogen bonding as dominant, reflecting an enthalpy-driven process. In RAW264.7 cells, PAPC more effectively suppressed LcTLP-induced NO, TNF-α, and IL-6 secretion by coating LcTLP surface. However, oligomeric proanthocyanidins occupied LcTLP active site by binding to the key residues, including GLU84 and TYR85.
Authors
- Zhuoyan Hu
- Xuwei Liu (ORCID: https://orcid.org/0000-0003-4954-2751)
- YJ Li
- Carine Le Bourvellec
- Chibuike C. Udenigwe (ORCID: https://orcid.org/0000-0001-8802-7707)
- Kai Wang
- Lei Zhao (ORCID: https://orcid.org/0000-0001-9928-3861)
Institutions
- South China Agricultural University (CN)
- University of Ottawa (CA)
- The University of Melbourne (AU)
- Université d'Avignon et des Pays de Vaucluse (FR)
- Nutrition Sciences (Belgium) (BE)
- Ecosystem Sciences (AU)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1021/acs.jafc.5c17962
- Primary Topic
- Biochemical Analysis and Sensing Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province