Antioxidant Reactivity of Nickel and Zinc Porphyrins Revealed by Electrochemical, Spectroscopic and Molecular Modelling Approaches
). Molecular dynamics and MM-GBSA analyses confirmed greater structural stability and stronger binding for the NiTPP-Keap1 complex. These findings highlight a complementary antioxidant behavior, where ZnTMPP favors direct radical scavenging, while NiTPP shows enhanced protein recognition and stabilization.
Authors
- Elhafnaoui Lanez (ORCID: https://orcid.org/0000-0002-6543-2547)
- Lazhar Bechki (ORCID: https://orcid.org/0000-0002-2242-8310)
- Mohammed Larbi Benamor (ORCID: https://orcid.org/0000-0002-6972-4221)
- Salah Neghmouche Nacer (ORCID: https://orcid.org/0000-0002-9381-8973)
- Lalmi Zerrouk
- Samra Hamada
- Touhami Lanez (ORCID: https://orcid.org/0000-0002-3978-7635)
- Ouafa Zouari Ahmed (ORCID: https://orcid.org/0009-0000-6115-9160)
- Yahia Bekkar (ORCID: https://orcid.org/0000-0001-5816-2043)
- Mohammed Khezzane
- Ilham Karkouri
- Taher M. Abdelhameed
- Kaouthar Houiti
Institutions
- University of Ouargla (DZ)
- Wrocław University of Science and Technology (PL)
- Institute for Biodiversity (DE)
- Exact Sciences (United States) (US)
- Medical Technologies (Czechia) (CZ)
- Life University (US)
Publication Details
- Journal
- Free Radical Research
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1080/10715762.2026.2672453
- Primary Topic
- Electrochemical sensors and biosensors
- Type
- article
- Field-Weighted Citation Impact
- 0.00