Liposome-mediated delivery of a ruthenium-based metallodrug to overcome cisplatin resistance in osteosarcoma
, treatment with liposomal Ru3 in mice bearing cisplatin-resistant xenografts produced superior therapeutic outcomes and was better tolerated than cisplatin, alleviating its systemic toxicity. Overall, these findings support ruthenium-based metallodrugs delivered via liposomes as promising alternatives to platinum-based chemotherapy for osteosarcoma management.
Authors
- Fernando de Andrés (ORCID: https://orcid.org/0000-0003-1076-0743)
- Ángel Ríos (ORCID: https://orcid.org/0000-0003-1728-3097)
- Elena Domínguez‐Jurado (ORCID: https://orcid.org/0000-0003-4235-7561)
- Verónica Rey (ORCID: https://orcid.org/0000-0001-9362-1700)
- Enol Álvarez-González (ORCID: https://orcid.org/0000-0002-6701-9836)
- Mar Rodríguez-Santamaría (ORCID: https://orcid.org/0009-0007-1393-8566)
- Carmen Huergo
- Dzohara Murillo (ORCID: https://orcid.org/0000-0001-7684-8508)
- Andrea Ferreras
- Iván Bravo
- Borja Gallego
- Adela A. Fernández-Velasco
- Ana S. Indurain
- Paula Díez
- René Rodríguez (ORCID: https://orcid.org/0000-0002-0768-7306)
- Iván Fernández-Vega
- Carlos Alonso-Moreno (ORCID: https://orcid.org/0000-0002-7588-0781)
Institutions
- Universidad de Oviedo (ES)
- Gobierno del Principado de Asturias (ES)
- Instituto de Biomedicina y Biotecnología de Cantabria (ES)
- Hospital Universitario Central de Asturias (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Instituto de Investigación Sanitaria del Principado de Asturias (ES)
- University of Castilla-La Mancha (ES)
Publication Details
- Journal
- Drug Delivery
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1080/10717544.2026.2671485
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00