Empagliflozin targets a renal neuro-epithelial-immune axis in heart failure
, it significantly reduced NE-induced SGLT2 expression and interleukin-6 (IL-6) release by HK-2 human proximal tubule epithelial cells. These findings support a model in which SGLT2 inhibitors confer renoprotection in HF by suppressing renal sympathetic hyperactivity, independently of the intrarenal renin-angiotensin system, thereby disrupting a maladaptive renal neuro-epithelial-immune axis and promoting a reparative macrophage phenotype.
Authors
- Danúbia Silva dos Santos (ORCID: https://orcid.org/0000-0002-7278-7143)
- Adriana C. C. Girardi (ORCID: https://orcid.org/0000-0003-3715-6917)
- João Carlos Ribeiro-Silva (ORCID: https://orcid.org/0000-0001-6350-2321)
- Andrey J. Serra (ORCID: https://orcid.org/0000-0002-7919-704X)
- Larissa Ferreira dos Santos
- Erika F. Jesus
- Livia C. Simonete
- Jennifer Coelho
- Andreia Boaro
- Flavia L. Martins (ORCID: https://orcid.org/0000-0002-3115-4526)
- Jose Wilson Correa do Nascimento (ORCID: https://orcid.org/0000-0002-9580-3361)
- Ednei L. Antonio
- Raphael E. Szawka
Institutions
- Universidade Federal de Minas Gerais (BR)
- Universidade de São Paulo (BR)
- SUNY Upstate Medical University (US)
- Universidade Federal do Amazonas (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- American Journal of Physiology-Cell Physiology
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1152/ajpcell.00209.2026
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico