Discovery of 4-carboxylate-1,2,3-triazine 1-oxide, their 1,2,3-triazine, and the 3,6-dihydro analogs, as new agents against Chagas diseases and Leishmaniasis
= 0.46 μM) similar to miltefosine against promastigotes of L. mexicana, and 1,2,3-triazine (2i) reduced parasitemia by up to 70 % in an in vivo mouse model. These results are the first report of 4-carboxylate-1,2,3-triazine 1-oxides and their deoxygenated and reduced analogs as trypanocidal and leishmanicidal agents, encouraging their use for the development of new therapeutic alternatives against these neglected parasitic diseases.
Authors
- Luca De Angelis (ORCID: https://orcid.org/0000-0001-7372-6628)
- Citlali Vázquez (ORCID: https://orcid.org/0000-0001-7783-1708)
- Manuel J. Chan-Bacab
- Mariana Mendoza-Conde
- José M. Quintero-Solano (ORCID: https://orcid.org/0009-0006-5729-3344)
- Adriana Moreno-Rodriguez
- Emma Saavedra
- Eyra Ortiz-Pérez
- Luis M. Sánchez-Palestino
- Gildardo Rivera (ORCID: https://orcid.org/0000-0001-9842-4167)
- Diana V. Navarrete-Carriola
- Michael P. Doyle
- Mario A. Bautista-Hernández
Institutions
- Autonomous University of Campeche (MX)
- Instituto Nacional de Cardiología (MX)
- The University of Texas at San Antonio (US)
- Instituto Politécnico Nacional (MX)
- Benito Juárez Autonomous University of Oaxaca (MX)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1016/j.biopha.2026.119490
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Consejo Nacional de Ciencia y Tecnología
- Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional