Portable Vibronic Near-Infrared Tumor Disruption Platform: A Preclinical Translational Proposal for Feedback-Controlled Molecular Activation Therapy

This preprint presents a conceptual translational proposal for a portable near-infrared (NIR) vibronic tumor disruption platform inspired by recent aminocyanine molecular activation studies. The proposed system integrates targeted cyanine-based molecular agents, adaptive optical excitation, fluorescence-assisted feedback control, and low-thermal operation to explore non-conventional photonic approaches for selective tumor cell disruption. The manuscript outlines the scientific background, proposed engineering architecture, feedback-control framework, potential applications, and key limitations of the approach while emphasizing that the platform remains preclinical and experimentally unvalidated for human therapeutic use.