Salivary transcriptomic study to understand the molecular effects of feeding dysregulation in opioid-exposed neonates born late preterm
(ΔCt 15.44 ± 2.76 vs 13.84 ± 4.03, p = 0.054), and this was accompanied by greater milk consumption in the first week of life (average of 24.2 mL/kg/day). Male sex, withdrawal severity, maternal polysubstance, and methadone use were associated with increased need for tube feeding.ConclusionModulation of hypothalamic/reward and inflammation genes may contribute to the need for tube feeding and its associated risks in opioid-exposed late preterm neonates.
Authors
- May J. Chow
- Devika Lekshmi (ORCID: https://orcid.org/0009-0000-2139-4641)
- Kiran Singh (ORCID: https://orcid.org/0000-0002-2592-6534)
- William Lin (ORCID: https://orcid.org/0009-0005-7819-4583)
- Francesca Carasi-Schwartz
- Mario Cordova
- Elizabeth Yen (ORCID: https://orcid.org/0000-0002-5916-3299)
- Ronnelle King
- Celia Rubien (ORCID: https://orcid.org/0009-0000-4912-8505)
Institutions
- Tufts University (US)
- Tufts Medical Center (US)
- Tufts Children's Hospital (US)
Publication Details
- Journal
- Journal of Neonatal-Perinatal Medicine
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1177/19345798261450464
- Primary Topic
- Prenatal Substance Exposure Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Drug Abuse