Lipid Nanoparticle-Based αHTRA1 mRNA Improves Pancreatic Ductal Adenocarcinoma Redox Microenvironment by Suppressing HTRA1/HIF-1 Signaling
-Cre (KC) mouse pancreatic organoid models, and the results indicate that the drug, by inhibiting the hypoxia-inducible factor-1 (HIF-1) signaling pathway, improves the tumor microenvironment and can effectively suppress the progression of PDAC. The mRNA drugs based on LNP designed and synthesized in this study have good therapeutic potential for PDAC, providing new potential drugs for targeted therapy of PDAC.
Authors
- Deshi Dong (ORCID: https://orcid.org/0000-0003-3266-4314)
- 孔欣
- Xinya Zhao (ORCID: https://orcid.org/0000-0001-5856-347X)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Y J Wu
- Hong Xiang
- Xufeng Tao (ORCID: https://orcid.org/0000-0002-4416-2234)
- Fangyue Guo
Institutions
- Dalian Medical University (CN)
- Integrative Medicine Institute (US)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Bioconjugate Chemistry
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1021/acs.bioconjchem.6c00013
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00