Spatial and temporal description of antimalarial drug resistance markers in Ghana using targeted amplicon deep sequencing
after two decades of chloroquine disuse in Ghana suggests the return of chloroquine-sensitive parasites. Therapeutic efficacy studies must be done to verify this observation. The opposing trends of sulfadoxine-pyrimethamine molecular markers highlight concern for its use in malaria prophylaxis in pregnancy and children. Molecular surveillance remains vital to mitigating the risk of artemisinin-resistant parasites evolving in malaria-endemic regions.
Authors
- Philip Opoku-Agyeman
- Nancy Odurowah Duah-Quashie (ORCID: https://orcid.org/0000-0001-8819-1793)
- Kwesi Z. Tandoh (ORCID: https://orcid.org/0000-0002-1628-2845)
- Naiki Attram (ORCID: https://orcid.org/0000-0003-0286-1990)
- Sena Matrevi
- Selassie Kumordjie
- Neils B. Quashie (ORCID: https://orcid.org/0000-0002-2538-0324)
- Esther Baafi
- Abigail Foriwaah Frimpong
- Joyce Ngoi
- Robert Duane Hontz
- Prince Ameyaw
- Selassie Adjoa Bruku
- Benjamin Abuaku
Institutions
- Naval Medical Research Command (US)
- University of Ghana (GH)
- Directorate-General for Research and Innovation (BE)
- Noguchi Memorial Institute for Medical Research (GH)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1128/aac.01902-25
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Armed Forces Health Surveillance Branch