<scp>GLP</scp> ‐1 Receptor Agonists and Psychiatric Outcomes in Adolescents: A Systematic Review and Meta‐Analysis
AIMS: To assess the association between GLP-1 receptor agonists (GLP-1 RAs) and psychiatric outcomes in adolescents. MATERIALS AND METHODS: and used sensitivity and subgroup analyses to test robustness of our data. We assessed risk of bias using RoB 2 (randomized trials) and ROBINS-I (observational studies) tools. We graded the certainty of evidence using the GRADE framework. RESULTS: = 50.4%). CONCLUSIONS: GLP-1 RAs were not associated with higher rates of suicidal behaviour or depression in adolescents. Pooled analysis suggested a possible lower risk of suicidal ideation, although this finding should be interpreted cautiously.
Authors
- Túlio Konstantyner (ORCID: https://orcid.org/0000-0002-7931-9692)
- Marconi Abreu (ORCID: https://orcid.org/0000-0001-5996-0661)
- Izabella De Abreu
- Gianlucca Thomazini
- Bruno Lins de Souza
- Oscar Inácio de Mendonça Bisneto
- Jardeson Júnior (ORCID: https://orcid.org/0009-0007-4908-7660)
- Cynthia F. X. C. A. Silva (ORCID: https://orcid.org/0000-0003-1110-7762)
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Northwell Health (US)
- Universidade Federal do Ceará (BR)
- Universidade Federal de Campina Grande (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
- The University of Texas Southwestern Medical Center (US)
- Universidade Federal de São Paulo (BR)
- Pontifícia Universidade Católica de São Paulo (BR)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1111/dom.70864
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00