Non-invasive left ventricular contractility indices derived from thoracocardiography in rats
(r = 0.83, p < 0.001). This metric reflects the rapid rise in aortic flow at the onset of ejection and captures the inertial force generated by the ventricle to accelerate the proximal blood column; higher values therefore indicate a stronger contractile performance. These findings provide proof-of-concept that TCG can yield robust contractility surrogates without surgical access, enabling prescreening, longitudinal follow-up and potentially fully non-invasive hemodynamic monitoring in freely moving rodents.
Authors
- Julie Fontecave-Jallon (ORCID: https://orcid.org/0000-0001-5764-3144)
- François Boucher (ORCID: https://orcid.org/0000-0001-6897-9321)
- Stéphane Tanguy (ORCID: https://orcid.org/0000-0002-9532-9145)
- Charles Eynard (ORCID: https://orcid.org/0009-0000-7123-4064)
- Timothé Flenet (ORCID: https://orcid.org/0000-0002-7247-9693)
- Agathe Cambier
- Leandro Fontana-Pires (ORCID: https://orcid.org/0009-0002-7058-9730)
- Pierre-Yves Guméry
Institutions
- Institut polytechnique de Grenoble (FR)
- Centre National de la Recherche Scientifique (FR)
- Association pour l'Utilisation du Rein Artificiel dans la région Lyonnaise (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1038/s41598-026-52302-3
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Association Nationale de la Recherche et de la Technologie