Body Mass Index and All‐Cause, Cancer, and Cardiovascular Mortality in Adults Aged 16–50 Years With and Without Type 2 Diabetes: An Analysis of Primary Care Records in England

AIMS: To examine the association between body mass index (BMI) and risk of all-cause, cancer, and cardiovascular diseases (CVD) mortality among adults aged 16-50 years with and without type 2 diabetes (T2D). MATERIALS AND METHODS: We conducted a retrospective matched cohort study using primary care records from the Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES) and Office for National Statistics (ONS) mortality records. Individuals aged 16-50 years with T2D were matched (1: up to 10) to those without T2D by year of birth, sex, and general practice. Using flexible parametric survival models and competing risk approaches, we estimated hazard ratios (HRs) and 10-year cumulative incidences of all-cause and cause-specific mortality adjusted for confounders. RESULTS: , the 10-year cumulative incidence of all-cause mortality risk was 17.3% (95% CI: 13.9%, 20.6%) for individuals with T2D compared to 4.4% (95% CI: 4.0%, 4.7%) in those without. CONCLUSIONS: The excess risk of mortality associated with T2D was greatest at lower BMI, where absolute risk estimates were high.