Redefining Drug Immune Recognition: A Radically Reconfigured Molecular Architecture Enables Broad Fentanyl-Class Protection
range, preserved ventilation during respiratory challenge, and reduced brain fentanyl from 61.9 ± 10.0 to 17.2 ± 0.7 nM. These results reveal programmable antibody recognition, demonstrating that molecular class identity arises not from direct structural mimicry but through higher-order spatial and physicochemical relationships.
Authors
- Lisa M. Eubanks (ORCID: https://orcid.org/0000-0001-5288-6294)
- Rachel C. Steinhardt (ORCID: https://orcid.org/0000-0003-3371-8468)
- Arran W. Stewart (ORCID: https://orcid.org/0009-0001-6276-3922)
- Bin Zhou
- Kim D. Janda (ORCID: https://orcid.org/0000-0001-6759-4227)
Institutions
- Scripps Research Institute (US)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00991
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00