Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

tumor populations. Transcriptomic profiling demonstrated upregulation of adhesion, integrin clustering, and mechanosensing-associated genes, alongside downregulation of neuronal differentiation pathways, indicating a dual invasion and host suppression strategy. Comparative analyses of GBM-only constructs and DO-GBM ASMs revealed elevated expression of laminin subunits and enrichment of invasion-associated pathways, including PI3K-AKT-mTOR and TGF-β signaling, reflecting a shift toward an invasive state at the transcriptomic level. In vivo implantation of ASMs confirmed aggressive GBM infiltration and niche remodeling, highlighting the translational relevance. These findings suggest that it recapitulates the structural, molecular, and functional hallmarks of GBM invasion and tumor-driven remodeling of the host brain microenvironment.

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Publication Details

Journal
Advanced Healthcare Materials
Published
2026-05-11
DOI
https://doi.org/10.1002/adhm.202504842
Primary Topic
Cell Adhesion Molecules Research
Type
article
Field-Weighted Citation Impact
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article

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Fabien Delerue, Wonyoung Choi, Young Mee Jung, Yeonju Park et al.
Advanced Healthcare Materials
Cell Adhesion Molecules Research
article

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Fabien Delerue, Wonyoung Choi, Young Mee Jung, Yeonju Park, 권용대, Ann‐Na Cho, Michael Kassiou, Ho Sang Jung, Henry Robert Howard, Karrie M. Kiang, Shihui Chen, Gilberto Ka-Kit Leung, Summer Cao, Arthur Chien, Sang Jin Lee, Chao Liang, Kevin Zou, Ryohichi Sugimura
article en

Abstract

tumor populations. Transcriptomic profiling demonstrated upregulation of adhesion, integrin clustering, and mechanosensing-associated genes, alongside downregulation of neuronal differentiation pathways, indicating a dual invasion and host suppression strategy. Comparative analyses of GBM-only constructs and DO-GBM ASMs revealed elevated expression of laminin subunits and enrichment of invasion-associated pathways, including PI3K-AKT-mTOR and TGF-β signaling, reflecting a shift toward an invasive state at the transcriptomic level. In vivo implantation of ASMs confirmed aggressive GBM infiltration and niche remodeling, highlighting the translational relevance. These findings suggest that it recapitulates the structural, molecular, and functional hallmarks of GBM invasion and tumor-driven remodeling of the host brain microenvironment.

Advanced Healthcare Materials
The University of Sydney (AU), The University of Texas MD Anderson Cancer Center (US), University of Tennessee Health Science Center (US), Kangwon National University (KR), Korea University (KR), UNSW Sydney (AU), Kyung Hee University (KR), Cooperative Trials Group for Neuro-Oncology (AU), University of Hong Kong (HK), Macquarie University (AU)
Openalex Percentile: Top 6%
Cell Adhesion Molecules Research
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