Silver Nanoparticle–Conjugated Pyrimidine-Based BN6 Methanimine Derivative Improves DSS-Induced Inflammatory Bowel Disease in Zebrafish

BACKGROUND: Treatment for inflammatory bowel diseases (IBD) include immunosuppressant and steroids for managing the inflammation. Also, these treatments have many negative complications, limited efficacy, and development of drug resistance. OBJECTIVE: zebrafish model. METHODS: ), biochemical changes (SOD, CAT, GSH, and LDH), macrophage localization, oxidative stress and cellular damages were measured in a following AgNPs-BN6 treatment at concentrations of 40, 80, and 100 μM. RESULTS: . Additionally, AgNPs-BN6 treatment reduces oxidative stress markers, demonstrating its antioxidant properties. CONCLUSION: AgNPs-BN6 derivatives, especially at 80 μM, possess substantial anti-inflammatory and antioxidant properties, emphasizing their potential as effective therapeutic agents for inflammatory disease.