Hematological parameter dynamics in critically ill patients treated with oXiris®-based CRRT and CytoSorb® hemoadsorption: a prospective single-center study

BACKGROUND: are among the most widely applied hemoadsorption devices, but their impact on blood element kinetics has not been fully characterized. METHODS: (n = 30). Hemoglobin (Hb), hematocrit (Hct), erythrocytes (RBC), and platelets (PLT) were measured prior to and following hemoadsorption. Descriptive analyses and statistical tests were employed to evaluate between-group differences in hematologic parameters. Clinically relevant declines defined as ≥ 15% reduction in Hb, Hct, and RBC, and ≥ 50% in PLT were treated as events in time-to-event (TTE) analysis. RESULTS: group. CONCLUSION: is used. Larger multicenter studies with mechanistic biomarkers are needed to validate these findings.

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Publication Details

Journal
BMC Nephrology
Published
2026-05-12
DOI
https://doi.org/10.1186/s12882-026-04978-y
Primary Topic
Acute Kidney Injury Research
Type
article
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article

Hematological parameter dynamics in critically ill patients treated with oXiris®-based CRRT and CytoSorb® hemoadsorption: a prospective single-center study

Danica Momčićević, Peđja Kovačević, Milka Jandrić, Saša Dragić et al.
BMC Nephrology
Acute Kidney Injury Research
article

Hematological parameter dynamics in critically ill patients treated with oXiris®-based CRRT and CytoSorb® hemoadsorption: a prospective single-center study

Danica Momčićević, Peđja Kovačević, Milka Jandrić, Saša Dragić, Nikolina Spiric, Katarina Vucicevic, Tijana Kovačević, Jesús Villar, Grozdana Klječanin, Biljana Zlojuto
article en

Abstract

BACKGROUND: are among the most widely applied hemoadsorption devices, but their impact on blood element kinetics has not been fully characterized. METHODS: (n = 30). Hemoglobin (Hb), hematocrit (Hct), erythrocytes (RBC), and platelets (PLT) were measured prior to and following hemoadsorption. Descriptive analyses and statistical tests were employed to evaluate between-group differences in hematologic parameters. Clinically relevant declines defined as ≥ 15% reduction in Hb, Hct, and RBC, and ≥ 50% in PLT were treated as events in time-to-event (TTE) analysis. RESULTS: group. CONCLUSION: is used. Larger multicenter studies with mechanistic biomarkers are needed to validate these findings.

BMC Nephrology
St. Michael's Hospital (CA), University of Banja Luka (BA), Instituto de Salud Carlos III (ES), University of Belgrade (RS), Hospital Universitario de Gran Canaria Doctor Negrín (ES), Universidad del Atlántico (MX), Public Health Institute of the Republic of Srpska (BA), Fundación Canaria de Investigación Sanitaria (ES), University clinical center of Republika Srpska (BA)
Good health and well-being
Openalex Percentile: Top 6%
Acute Kidney Injury Research
DOIOpen Access PDFOpenAlex
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Hematological parameter dynamics in critically ill patients treated with oXiris®-based CRRT and CytoSorb® hemoadsorption: a prospective single-center study — Danica Momčićević, Peđja Kovačević, et al. · BMC Nephrology (2026) | TGRS Research Map | TGRS