Ceftazidime–avibactam drives mutations, insertion, or overexpression in blaKPC-2 and enhances biofilm-forming ability of KPC-producing Klebsiella pneumoniae
. The induction of CZA may reverse the sensitivity of certain antibiotics, providing a potential combination therapy for such drug-resistant bacterial infections. The biofilm-forming ability of a strain may be enhanced after CZA induction, which improves its adaptability to the environment.
Authors
- Fengjun Xia (ORCID: https://orcid.org/0000-0001-9871-0366)
- Y Hu
- Z.H. Liu (ORCID: https://orcid.org/0000-0002-9199-6493)
- M M Zou (ORCID: https://orcid.org/0009-0006-8204-9431)
- Yubing Xia (ORCID: https://orcid.org/0000-0002-2170-6227)
- Haolan Wang
- Haichen Wang
- Jun Li
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1038/s41598-026-52233-z
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hunan Province