Attenuating trauma- and cocaine-related intrusions by blocking memory reconsolidation with minocycline: protocol for a transdiagnostic randomized controlled trial
: This trial adopts a mechanistic framework to investigate whether minocycline-augmented memory reactivation modulates intrusions and associated neurobiological markers in PTSD and CUD. By directly targeting candidate memory mechanisms shared by both disorders, it evaluates a transdiagnostic reconsolidation-based approach and is expected to inform models of intrusive memory persistence and updating. The findings may guide future development of memory-focused interventions in trauma- and addiction-related disorders.
Authors
- Erich Seifritz (ORCID: https://orcid.org/0000-0002-7311-4426)
- Amelie Zacher (ORCID: https://orcid.org/0000-0003-2090-9476)
- Niklaus Zölch
- Michèle Loosli
- Charlotta Rühlmann
- Lina Dietiker
- Francesco Bavato (ORCID: https://orcid.org/0000-0002-3787-6706)
- Boris B. Quednow (ORCID: https://orcid.org/0000-0001-7933-2865)
- Luca B. Schmid (ORCID: https://orcid.org/0009-0008-3396-5964)
- Madalina Wernigg (ORCID: https://orcid.org/0000-0001-9129-454X)
- Sofia de’Sperati (ORCID: https://orcid.org/0009-0008-3705-5140)
- Birgit Kleim (ORCID: https://orcid.org/0000-0001-9114-2917)
Institutions
- University of Zurich (CH)
- University Hospital of Zurich (CH)
- École Polytechnique Fédérale de Lausanne (CH)
Publication Details
- Journal
- European Journal of Psychotraumatology
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1080/20008066.2026.2650920
- Primary Topic
- Memory and Neural Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universität Zürich