Morphological and molecular characterization of epithelial ovarian cancer: SEOM-SEAP consensus guidelines for biomarker integration in clinical practice
Epithelial ovarian cancer (OC) is the second leading cause of death among gynecologic malignancies and exhibits marked histological and molecular heterogeneity. Advances in tumor biology and targeted therapies have increased the need for accurate biomarker characterization. This updated consensus by the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP) reviews key morphological and molecular features for diagnosis and providing recommendations for biomarker assessment across major OC subtypes. The document addresses classical serum biomarkers, prognostic tools, and genomic alterations with therapeutic implications, including homologous recombination deficiency (HRD), BRCA1 and BRCA2 mutations, mismatch repair status, as well as other established and emerging biomarkers. Emphasis is placed on optimal sample selection, validated techniques, and multidisciplinary integration is required to ensure diagnostic quality. These recommendations aim to optimize prognostic stratification and guide personalized treatment strategies, ultimately improving clinical outcomes in ovarian cancer.
Authors
- M.J. Bermejo-Pérez
- Carmen García-Durán (ORCID: https://orcid.org/0000-0003-3836-6959)
- Sonia Gatius-Calderó
- Ignacio Romero (ORCID: https://orcid.org/0000-0001-8622-618X)
- Nuria Escudero-García (ORCID: https://orcid.org/0009-0006-6203-5681)
- Susana López-Agullo (ORCID: https://orcid.org/0009-0008-2364-3427)
- Maria-Pilar Barretina-Ginesta (ORCID: https://orcid.org/0000-0003-0074-6614)
- Gabriel Matheu (ORCID: https://orcid.org/0009-0003-6640-4243)
- Geanella Yange (ORCID: https://orcid.org/0009-0004-9955-2215)
- Eva Guerra-Alía (ORCID: https://orcid.org/0009-0002-5556-2337)
Institutions
- Hebron University (PS)
- Universitat de Lleida (ES)
- Instituto Cajal (ES)
- Hospital Universitari Arnau de Vilanova (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Marqués de Valdecilla University Hospital (ES)
- Institut Català d'Oncologia (ES)
- Hospital Universitario Son Espases (ES)
- Hospital Clínico Universitario Virgen de la Victoria (ES)
- Complejo Hospitalario de Pontevedra (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Instituto de Investigación Biomédica de Málaga (ES)
Publication Details
- Journal
- Clinical & Translational Oncology
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1007/s12094-026-04335-3
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca
- AstraZeneca España
- GlaxoSmithKline foundation
- Sociedad Española de Oncología Médica
- AbbVie Deutschland