Carbonylative Synthesis of β-Trifluoromethylated Heterocyclic Ketones through 1,2-Trifluoromethylation and Minisci Carbonylation of Alkenes
-heteroaryl substrates, including pyridine, quinoline, and isoquinoline, can all participate in the reaction. In addition, the reaction displays satisfactory compatibility with both terminal and internal alkene substrates.
Authors
- Ren-Guan Miao
- Xiao-Feng Wu (ORCID: https://orcid.org/0000-0001-6622-3328)
- Ru-Han A
Institutions
- Dalian Institute of Chemical Physics (CN)
- Chinese Academy of Sciences (CN)
- Leibniz Institute for Catalysis (DE)
- Dalian National Laboratory for Clean Energy (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1021/acs.orglett.6c01481
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- National Key Research and Development Program of China