Therapeutic Innovations for Monkeypox Inhibition

This review investigates biomaterial-based strategies for improved treatment of MPXV. We focus on emerging synthetic biomedical approaches to combating the virus. These include peptide nucleic acids, CRISPR-based systems, and small-molecule therapeutics. These methods work by targeting and blocking viral proteins and enzymes. Such synthetic platforms may help reduce viral transmission and minimize side effects. They also offer potential solutions to challenges such as viral resistance in humans. In addition, biomaterials contribute to the development of more stable and effective vaccines. Combining these biomaterials with mRNA technology provides a promising framework for future vaccine development. Overall, this review underscores biomaterial-driven antiviral systems as a major frontier in translational medicine with profound implications for global health and pandemic awareness.

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Publication Details

Journal
International Journal of Molecular Sciences
Published
2026-05-12
DOI
https://doi.org/10.3390/ijms27104307
Primary Topic
Poxvirus research and outbreaks
Type
article
Field-Weighted Citation Impact
0.00

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article

Therapeutic Innovations for Monkeypox Inhibition

Kamala Mitra, Debmalya Bhunia, Nayan De, Md Sorique Aziz Momin et al.
International Journal of Molecular Sciences
Poxvirus research and outbreaks
article

Therapeutic Innovations for Monkeypox Inhibition

Kamala Mitra, Debmalya Bhunia, Nayan De, Md Sorique Aziz Momin, Jhuma Bhadra, Achinta Sannigrahi
article en

Abstract

This review investigates biomaterial-based strategies for improved treatment of MPXV. We focus on emerging synthetic biomedical approaches to combating the virus. These include peptide nucleic acids, CRISPR-based systems, and small-molecule therapeutics. These methods work by targeting and blocking viral proteins and enzymes. Such synthetic platforms may help reduce viral transmission and minimize side effects. They also offer potential solutions to challenges such as viral resistance in humans. In addition, biomaterials contribute to the development of more stable and effective vaccines. Combining these biomaterials with mRNA technology provides a promising framework for future vaccine development. Overall, this review underscores biomaterial-driven antiviral systems as a major frontier in translational medicine with profound implications for global health and pandemic awareness.

International Journal of Molecular SciencesVol. 27(10)
Mahindra Group (India) (IN), Rochester Institute of Technology (US), Indian Association for the Cultivation of Science (IN), Cold Spring Harbor Laboratory (US), University of Arkansas at Fayetteville (US), The University of Texas Southwestern Medical Center (US)
Science and Engineering Research Board
Good health and well-being
Openalex Percentile: Top 6%
Poxvirus research and outbreaks
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