Threshold‐Gated DNA Nanocages Enable Programmable Quorum‐Like Sensing in Vesicle Communities

generated by a GOX-CAT positive-feedback circuit as the autoinducer, we achieved density-dependent signal accumulation and threshold-triggered reversible structural switching, thereby exhibiting key operational features of quorum-like sensing in vesicle-based communities. This platform provides a general model for studying community organization and cooperative behaviors, with potential applications in biomimetic sensing, programmable smart materials, and stimulus-responsive delivery systems.

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Publication Details

Journal
Small
Published
2026-05-12
DOI
https://doi.org/10.1002/smll.73751
Primary Topic
Advanced biosensing and bioanalysis techniques
Type
article
Field-Weighted Citation Impact
0.00

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article

Threshold‐Gated DNA Nanocages Enable Programmable Quorum‐Like Sensing in Vesicle Communities

Pengyan Hao, Yongxi Zhao, Na Wu, Di Lu et al.
Small
Advanced biosensing and bioanalysis techniques
article

Threshold‐Gated DNA Nanocages Enable Programmable Quorum‐Like Sensing in Vesicle Communities

Pengyan Hao, Yongxi Zhao, Na Wu, Di Lu, Xiaoya Sun
article en

Abstract

generated by a GOX-CAT positive-feedback circuit as the autoinducer, we achieved density-dependent signal accumulation and threshold-triggered reversible structural switching, thereby exhibiting key operational features of quorum-like sensing in vesicle-based communities. This platform provides a general model for studying community organization and cooperative behaviors, with potential applications in biomimetic sensing, programmable smart materials, and stimulus-responsive delivery systems.

Small
Xi'an Jiaotong University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 8%
Advanced biosensing and bioanalysis techniques
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