Luteolin Ameliorates Sepsis‐Induced Acute Lung Injury by Targeting RPTPα to Reprogram Macrophage M1–M2 Polarization
-induced zebrafish inflammation models. Collectively, our study reveals that RPTPα is a potential therapeutic target for modulating macrophage polarization. Moreover, LU may serve as a lead compound targeting RPTPα for the treatment of sepsis-induced ALI.
Authors
- Zhengping Liu (ORCID: https://orcid.org/0000-0002-4964-0258)
- Li-Wen Han
- Tai Wei (ORCID: https://orcid.org/0000-0002-9629-0158)
- Lina Yin
- Bo Han (ORCID: https://orcid.org/0000-0002-6509-0313)
- Zhi‐Yuan Lu (ORCID: https://orcid.org/0000-0001-8969-6195)
- Ze‐Kun Chen
- Yang Chen
- Ke‐Wu Zeng (ORCID: https://orcid.org/0000-0003-1082-6327)
- Wei Yu
- Ling Li
- Si‐Miao Yu
Institutions
- Shihezi University (CN)
- Peking University (CN)
- Shandong Academy of Pharmaceutical Sciences (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- ChemBioChem
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1002/cbic.70379
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing Municipal Natural Science Foundation