Outcome comparisons of controlled ovarian hyperstimulation protocols in adenomyosis patients: a real-world retrospective cohort study

OBJECTIVE: To compare the efficacy of different COH protocols on pregnancy outcomes in adenomyosis patients. STUDY DESIGN: A real-world retrospective cohort study analyzed 1486 IVF-ET cycles in adenomyosis patients who received COH regimens between 2018 and 2021. Pregnancy outcomes were compared among patients under different COH protocols. RESULTS: = 0.995), with significantly less gonadotropin used in the antagonist protocol. CONCLUSIONS: In adenomyosis patients, the long/ultra-long provided better fresh-cycle outcomes. While the antagonist protocol had lower overall pregnancy rates, it preserved cumulative pregnancy rates in young patients with normal ovarian reserves and reduced gonadotropin exposure.