Chemiluminescent Probe Enables Enhanced Visualization of Acute Ischemic Stroke via Acetylcholinesterase Activation
imaging with AhCL produced a 3-23-fold enhancement in high-contrast chemiluminescent signals across differentially hypoxia-exposed brain tissues within 1 h, clearly distinguishing tissue hypoxia levels. Notably, AChE activation allowed the probe to effectively differentiate hypoxia-induced brain injury, potentially providing critical guidance for clinical intervention. This study establishes AChE as a robust biomarker for AIS and offers a potential tool for timely diagnosis and assessment.
Authors
- Xifeng Sun (ORCID: https://orcid.org/0000-0001-5018-8230)
- Tingting Geng
- Panpan Liu (ORCID: https://orcid.org/0000-0001-6439-2670)
- Ming Sun
- Lili Zhu (ORCID: https://orcid.org/0000-0003-1957-973X)
- Xiang Shi (ORCID: https://orcid.org/0000-0003-1963-3337)
- Zhixiong Zheng
- Yueyue Zhang (ORCID: https://orcid.org/0000-0001-7271-1555)
- Mingming Liu
- Yajing Zhang
- Peng Gao
- Huan Yu
Institutions
- Shenyang Pharmaceutical University (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Active Space Technologies (Portugal) (PT)
- Morgan State University (US)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1021/acs.analchem.5c08270
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China