Olink Proteomic Research in Colorectal Cancer: Redefining Minimally Invasive Surgery through Biomarker-driven Insights

The study by Yan and colleagues in the Journal of Proteome Research (2025) represents a valuable contribution to the emerging integration of molecular profiling in surgical oncology. 1By employing high-fidelity Olink proteomic profiling, the research provides the first plasma proteomic comparison between Endoscopic Super-Minimally Invasive Surgery (ESMIS) and laparoscopic surgery (LS) for colorectal cancer (CRC), moving beyond traditional clinical metrics to propose a data-driven framework for understanding surgical trauma and tumor biology.The identification of candidate diagnostic biomarkers (AMN, LRP1, FOXO1, PTPRJ) and surgery-specific injury markers (CALCA, PDGFC) offers tan-