Clinical and morphological substantiation of the effectiveness of topical antimicrobial therapy for acute tonsillopharyngitis

Since the COVID-19 pandemic, there has been an increase in the inappropriate use of systemic antibiotics for acute upper respiratory tract infections. In 75% of cases, doctors prescribe antibiotics despite the fact that 80% of such diseases have a viral etiology. The main causes are the following: challenges in differential diagnosis of the causative agent, ignoring clinical guidelines and pressure from patients. Consequences: growth of antibiotic resistance, increased incidence of chronic diseases, side effects, high healthcare costs. OBJECTIVE: To determine the effectiveness of Dorithricin combination drug in patients with acute non-streptococcal tonsillopharyngitis using cytomorphometry. MATERIAL AND METHODS: A study for evaluating the effectiveness of Dorithricin combination drug, which contains tyrothricin and has a two-stage mechanism of action that prevents the development of resistance, in patients with acute non-streptococcal tonsillopharyngitis using cytomorphometry was carried out at the department of otorhinolaryngology of the Russian University of Medicine. The study included 30 patients with acute tonsillopharyngitis of non-streptococcal etiology, aged 22-62 years, with a disease duration of 1 to 3 days at the time of inclusion and a negative rapid strep test result. Using subjective and objective research methods, data indicating the high effectiveness of Dorithricin combination drug (in the treatment of inflammatory diseases of the oropharynx) were obtained. CONCLUSION: The use of Dorithricin drug in the treatment of acute tonsillopharyngitis not only allows to rapidly relieve inflammation but also restores the overall well-being of patients without the risk of developing antibiotic resistance.