Sulfonyl Pyrazoles as Sustainable Dual Functional Group Transfer Reagents: AlCl <sub>3</sub> Promoted Transfer of Sulfonyl and Pyrazole Groups
activates the S-N bond toward cleavage, and in the second, a sulfoximine nucleophilically attacks the sulfonyl group, resulting in the elimination of the pyrazole moiety. This process yields sulfonyl amidines, compounds with significant medicinal relevance, while the liberated pyrazole effectively participates in subsequent reactions with Michael acceptors. Notably, the protocol operates without the need for transition-metal catalysts and exhibits broad substrate scope along with excellent functional group tolerance.
Authors
- Sumeer Ahmed (ORCID: https://orcid.org/0000-0001-8625-9504)
- Harpreet Kour (ORCID: https://orcid.org/0000-0002-1573-3333)
- Praveen Kumar Verma (ORCID: https://orcid.org/0000-0002-0505-3502)
- Sanghapal D. Sawant (ORCID: https://orcid.org/0000-0002-6224-3214)
- Parvinder Pal Singh (ORCID: https://orcid.org/0000-0001-8824-7945)
- Shivangani Mahajan
- Ram Birajdar
Institutions
- National Chemical Laboratory (IN)
- Advanced Pharma (US)
- Indian Institute of Integrative Medicine (IN)
- Shoolini University (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1021/acs.joc.5c03023
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Council of Scientific and Industrial Research, India