Tackling the Orexin Conundrum: An Optimized LC–MS/MS Method Demonstrates Accurate CSF Quantification and Absence in Peripheral Blood
= 0.297). This study establishes a high-specificity analytical framework as a practical reference standard for refined sleep disorder diagnostics and confirms that CSF orexin-A remains the currently the most reliable clinical biomarker.
Authors
- Shuqin Zhan (ORCID: https://orcid.org/0000-0002-2036-4392)
- Zhengwen Xu
- Zhu Cao
- Hui Li (ORCID: https://orcid.org/0000-0001-9198-3951)
- Y M Zhang
- Huimin Zhang (ORCID: https://orcid.org/0000-0002-7343-5641)
- Y L Yang
- J Y Han
- Yanhong Zhai
- Dong Wang
- Yan Cao (ORCID: https://orcid.org/0009-0009-4577-5815)
Institutions
- Capital Medical University (CN)
- IONICS Mass Spectrometry (Canada) (CA)
- Shanghai Optical Instrument Research Institute (CN)
- Beijing Obstetrics and Gynecology Hospital (CN)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1021/acs.analchem.6c00454
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China