An Integrative Omics Approach Identifies Genetic Effect of CircRNA on Nonsyndromic Cleft Lip With or Without Cleft Palate Susceptibility

= 7.85E-04]. Adding these SNPs to wGRS improved AUC to 0.707 for NSCL/P prediction. Additionally, rs629772 T>C increased the binding affinity of hsa-miR-628-5p and circPRKCE, and rs365132 G>T increased the binding of hsa-miR-374c-3p and hsa-miR-3916 to circUIMC1, followed by the alteration of 9, 6, and 65 target genes for hsa-miR-628-5p, hsa-miR-374c-3p, and hsa-miR-3916, respectively, which participated in key biological pathways.ConclusionThis study indicated genetic effects in circRNA MREs associated with NSCL/P, offering insights into the genetic regulation and functional mechanisms of the disease.