Staging intermediate hyperglycaemia for type 2 diabetes prevention: the ELSA-Brasil study

AIMS/HYPOTHESIS: levels. METHODS: levels. We additionally assessed these staging schemas requiring an initial clinical score cutoff of ≥10% probability of developing diabetes in 10 years before proceeding to laboratory testing. We calculated baseline insulin responsiveness (insulin secretion-sensitivity index-2, ISSI-2) and the frequency of an estimated high risk of complications (Whitehall subphenotype clusters) across stages. We estimated relative risks of developing diabetes ascertained by self-report and glucose measurements after a 5.31 (0.44) year follow-up using robust Poisson regression with an offset for person-years. We calculated the prognostic properties of staging schemas in the prediction of diabetes. RESULTS: staging schemas were superior to the binary categorisation of prediabetes (intermediate hyperglycaemia). CONCLUSIONS/INTERPRETATION: schemas. Applying a predictive clinical score in staging reduced laboratory testing and false positives.