Development and Evaluation of Intranasal Nanostructured Lipid Carriers Encapsulating Donepezil HCl and Caesalpinia bonduc Seed Extract for Targeting Alzheimer’s Disease: <i>in vitro</i> and <i>in vivo</i> evaluation
behavioral studies on AD-induced rats demonstrated significantly improved memory and cognition (p < 0.05) following nasal NLC administration. The DPZ-CBSE NLCs present a promising, safe, and non-invasive strategy for effective AD management.
Authors
- Janhavi Nimbalkar
- Shivakumar H.N. (ORCID: https://orcid.org/0000-0003-1596-9941)
- Prasad Kadam (ORCID: https://orcid.org/0000-0002-9599-2123)
- Avinash Tekade (ORCID: https://orcid.org/0000-0001-8564-1859)
- Rushikesh Shinde (ORCID: https://orcid.org/0009-0003-0304-3057)
- Manoj Aswar (ORCID: https://orcid.org/0000-0001-7159-4326)
Institutions
- Mitra Biotech (India) (IN)
- KLE Academy of Higher Education and Research (IN)
- Marathwada Mitra Mandal's College of Pharmacy
- Savitribai Phule Pune University (IN)
Publication Details
- Journal
- Journal of drug targeting
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1080/1061186x.2026.2671309
- Primary Topic
- Biological Stains and Phytochemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.00