Prevalence and outcomes of anxiety and depression in fibrotic interstitial lung disease: a registry-based analysis
Anxiety and/or depression are common in fibrotic interstitial lung disease (ILD) but with unclear treatment implications. A prospective multicentre registry of 4009 patients was used to evaluate the association of depression and/or anxiety with clinical features and outcomes in fibrotic ILD.Anxiety and/or depression was associated with female sex and worse dyspnoea and cough but not lung function or ILD medication intolerance. Having anxiety and/or depression was associated with greater odds of patients declining referral for lung transplant assessment.Patients with anxiety and/or depression experience worse ILD symptoms and are more likely to decline referral for lung transplant assessment.
Authors
- H. Manganas
- J H Fisher
- N. Avitzur
- Deborah Assayag (ORCID: https://orcid.org/0000-0002-2497-9984)
- Luca Alessandro Belmonte
- Daniel-Costin Marinescu (ORCID: https://orcid.org/0000-0003-3358-7699)
- Veronica Marcoux (ORCID: https://orcid.org/0000-0001-5890-3227)
- Christopher J Ryerson (ORCID: https://orcid.org/0000-0003-1049-393X)
- Kerri A Johannson
- Mauro Degrassi
- Martin R J Kolb
- Gillian Goobie
Institutions
- University of British Columbia (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- St. Paul's Hospital (CA)
- University of Saskatchewan (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
- McGill University (CA)
- McMaster University (CA)
Publication Details
- Journal
- Thorax
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1136/thorax-2026-225085
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Boehringer Ingelheim
- Canadian Pulmonary Fibrosis Foundation